I was tossing around ideas with Matt on the ride home from Nightmare Circle this weekend and I had what I think would be an innately humorous and fun idea. We run a game set in some college in the US and square off the warring factions of the nerds and the jocks, in a bitter competition of pranks, sabotage, public humiliation, and overall outdoing, to the end of some asinine goal. One side could be one of the on-campus fraternities and the other a dorm for the science/engineering/computing/etc. students. There would of course also be roles for members of faculty and if it could be managed, a neutral sorority house.
I know everyone can spend a couple of minutes thinking about how uproariously funny the in-faction RP would be, let alone the interaction between each side.